The human insular cortex, or simply “insula”, has gained the attention from researchers since the early 19th century. But a 3D cytoarchitectonic map of the insula that could be linked to neuroimaging studies addressing different cognitive tasks was thus far not available.
The research team from the University of Düsseldorf and Forschungszentrum Jülich analysed images of the middle posterior and dorsal anterior insula of ten human brains and used statistical mapping to calculate 3D-probability maps of seven new areas. The probability maps reflect the interindividual variability and localisation of the areas in a three-dimensional space.
Brain areas with differences in their cytoarchitecture - or the organisation of their cellular composition - also likely differ in function. Based on this hypothesis, the researchers aimed to better understand the differences in the microstructure of the insula, and to identify areas that may correlate with its diverse and complex multifunctionality.
The team found that the microstructure of the insula has a remarkable diversity and a broad range of cytoarchitectonic features, which might be the basis for the complex functional organisation in this brain region.
A cluster analysis based on cytoarchitecture resulted in the identification of three superordinate microstructural clusters in the insular cortex. The clusters revealed significant differences in the microstructure of the anterior and posterior insula, reflecting systematic functional differences between both entities.
The new maps are now openly available in the Multilevel Human Brain Atlas on EBRAINS to support future studies addressing relations between structure and function in the human insula.
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