Optimise a single cell model against experimental data on HPC resources using the Hodgkin-Huxley Neuron Builder. With this web-browser application, users can build and optimise their own neuron models, implemented through the NEURON simulation environment, thanks to the BluePyOpt optimisation library. The HPC resources required are offered by EBRAINS free of charge.
For optimizations with the Hodgkin-Huxley Neuron Builder, you may choose a model from the HBP Model Catalog (i.e. the single cell hippocampal models) or upload your own NEURON model files. Enable extraction of the electrophysiological properties used to optimise a NEURON model with the Feature Extraction utility (available on EBRAINS). Once a model has been optimised, it can be fetched from the remote HPC systems and run through the Single Cell in silico Experiment tool (BlueNaas) (see documentation) which allows the user to set the simulation parameters and download the simulated activity in text format for further statistical analysis. Both tools are integrated in the web application.
Additionally, the Hodgkin-Huxley Neuron Builder allows the user to save the optimised model in the HBP Model Catalog, which is publicly available to the scientific community.
A free EBRAINS account is required to run this web application.