JavaScript is required to consult this page

NESTML is a domain-specific language that supports the specification of neuron models in a precise and concise syntax. It was developed to address the maintainability issues that follow from an increasing number of models, model variants, and an increased model complexity in computational neuroscience. Our aim is to ease the modelling process for neuroscientists both with and without prior training in computer science. This is achieved without compromising on performance by automatic source-code generation, allowing the same model file to target different hardware or software platforms by changing only a command-line parameter. While originally developed in the context of NEST Simulator, the language itself as well as the associated toolchain are lightweight, modular and extensible, by virtue of using a parser generator and internal abstract syntax tree (AST) representation, which can be operated on using well-known patterns such as visitors and rewriting. Model equations can either be given as a simple string of mathematical notation or as an algorithm written in the built-in procedural language. The equations are analyzed by the associated toolchain ODE-toolbox, to compute an exact solution if possible or to invoke an appropriate numeric solver otherwise.

Other software

All software

3DSpineMFE

A MATLAB® toolbox that given a three-dimensional spine reconstruction computes a set of characteristic morphological measures that unequivocally determine the spine shape.

Modelling and simulation

Arbor

Arbor is a high-performance library for computational neuroscience simulations with multi-compartment, morphologically-detailed cells, from single cell models to very large networks. Arbor is written from the ground up with many-cpu and gpu architectures in mind, to help neuroscientists effectively use contemporary and future HPC systems to meet their simulation needs. Arbor supports NVIDIA and AMD GPUs as well as explicit vectorization on CPUs from Intel (AVX, AVX2 and AVX512) and ARM (Neon and SVE). When coupled with low memory overheads, this makes Arbor an order of magnitude faster than the most widely-used comparable simulation software. Arbor is open source and openly developed, and we use development practices such as unit testing, continuous integration, and validation.

Modelling and simulationCellular level simulation

BioExcel Building Blocks

BioExcel Building Blocks Workflows is a collection of biomolecular workflows to explore the flexibility and dynamics of macromolecules, including signal transduction proteins or molecules related to the Central Nervous System. Molecular dynamics setup for protein and protein-ligand complexes are examples of workflows available as Jupyter Notebooks. The workflows are built using the BioBB software library, developed in the framework of the BioExcel Centre of Excellence. BioBBis a collection of Python wrappers on top of popular biomolecular simulation tools, offering a layer of interoperability between the wrapped tools, which make them compatible and prepared to be directly interconnected to build complex biomolecular workflows.

Modelling and simulationMolecular and subcellular simulation

Make the most out of EBRAINS

EBRAINS is open and free. Sign up now for complete access to our tools and services.

Ready to get started?Create your account