The EBRAINS multilevel human brain atlas provides detailed information on anatomy, connectivity, and function. It links macroanatomical concepts and their intersubject variability with measurements of the microstructural composition and intrinsic variance of brain regions.
The multilevel human brain builds on the Julich-Brain cytoarchitectonic maps as a unifying principle of organisation, which are defined at the microscopic scale and well established as a reference for anatomical assignment of neuroimaging signals. The maps reflect intersubject variability in space and localization (“probability maps”).
They are complemented with maps covering complementary aspects of brain organisation, represented by fiber bundles from MRI tractography and maps of functional modes. The atlas supports multiple reference spaces, including the MNI Colin27, ICBM 152 2009c and average spaces which are common in functional imaging and whole-brain connectivity studies. It integrates these with the microscopic resolution BigBrain model as a link from the macroscopic to the cellular scale. Brain regions are characterised by multiple levels of brain connectivity and multimodal regional measurements including neurotransmitter receptor densities, cell densities, fiber orientations, genomics and physiological data.
siibra-explorer is built around an interactive 3D view of the brain displaying a unique selection of detailed templates and parcellation maps for the human, macaque, rat or mouse brain, including BigBrain as a microscopic resolution human brain model at its full resolution of 20 micrometres.
siibra-api is an HTTP API for querying and retrieving contents of EBRAINS atlases. Originally built as a backend service for the interactive atlas viewer siibra-explorer, the API has been documented for connecting the brain atlases to other applications and web services.
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