Ginkgo/MEDUSA

Ginkgo/MEDUSA (Microstructure Environment Designer Using Sphere Atoms) is a HPC compatible simulation tool that allows an all-in one simulation of brain tissue microstructure and their diffusion MRI signal relying on 3 simulation features:

1. Simulation of realistic geometries representing cell membranes populating brain gray and white matters to create virtual tissues using a generative approach called MEDUSA,
2. Simulation of the diffusion process of water molecules present within tissues using a Monte-Carlo approach,
3. Simulation of the attenuation of the diffusion MRI signal for any tuning of a diffusion-weighted MRI pulse sequence (Pulsed Gradient Spin Echo, Oscillating Gradient Spin Echo, Abritrary Gradient Spin Echo, ….).

The Ginkgo/MEDUSA tool is dedicated to the development of computational models of brain tissue microstructure in order to go beyond existing analytical models known to be limited to accurately represent the complexity of brain cellular environments