JuGEx

The JuGEx tool combines the analytical benefits of The Allen Human Brain Atlas and the EBRAINS Human Brain Atlas for integrating tissue transcriptome and probabilistic brain segregation.

  • Combine the analytical benefits of the comprehensive maps of the EBRAINS human brain atlas with the transcriptomics data offered by the Allen Brain AtlasObtain quantitative measures of labelled structures in atlas-defined regions
  • Perform your analysis in Python, Matlab, or using an intuitive graphical plugin of the EBRAINS Interactive Atlas Viewer

JuGEx is a tool that combines data from two repositories, the Allen Human Brain Atlas and the EBRAINS Human Brain Atlas, to provide detailed insights into how gene activities and microanatomical architectures contribute to brain function and dysfunction. The Allen Human Brain Atlas contains regional gene expression data, while the EBRAINS human brain atlas offers three-dimensional cytoarchitectonic maps reflecting interindividual variability. JuGEx integrates tissue transcriptome and probabilistic brain segregation data, allowing researchers to explore the complex relationships between genetic expression, brain structure, and function. With JuGEx, researchers can gain a deeper understanding of the intricate connections between genes and cognition, which can inform the development of new treatments for brain disorders and improve our understanding of brain function in health and disease.

Differential gene expression analysis using EBRAINS human brain atlas

The principle of JuGEx is simple: Select two brain areas from the EBRAINS human brain atlas and a set of candidate genes of your interest. JuGEx will use probabilistic maps of brain regions to extract gene expression measurements from the Allen Brain Atlas (© 2015 Allen Institute for Brain Science), and perform a differential analysis of the genes and associated factors in the two brain regions. As a result, you obtain the computed p-values together with the extracted transcriptomics data, and can visually inspect the locations of the data samples in atlas reference space.
 

JuGEx is available to you in different forms: As a Matlab implementation, as a Python implementation included in the siibra Python client, and as an interactive Plugin included in the EBRAINS Atlas Viewer, accessible from your browser right away. Choose the implementation that suits you the best.
 

Use JuGEx as graphical plugin of the interactive atlas viewer
Use JuGEx as a Python module included in the siibra client
Read the original publication
See the original Matlab Implementation

Related Publications

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Publication

Integration of transcriptomic and cytoarchitectonic data implicates a role for MAOA and TAC1 in the limbic-cortical network

Bludau S., Mühleisen T. W., Eickhoff, A. B., Hawrylycz M. J., Cichon S., Amunts K. (2018) Brain Structure and Function
Launch online
Source Code
Contributors
KA SC MJH SBE TWM SB

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