User Documentation
Level: Advanced
Level: Advanced
Segmenting a simulation of a model cell - Introduction
When I'm trying something new, I find that it helps to keep everything as simple as possible, so I can focus all of my effort on the real problem. Using toy models with minimal instrumentation saves time and effort, and keeping run times short speeds up debugging and eliminates the need to wade through piles of numbers.
For these reasons, my conceptual model is merely a spherical passive cell, with surface area 100 um2, driven by a current clamp that injects a constant current. The variable to be recorded is membrane potential. The model's membrane time constant and the duration of the injected current should be long enough that membrane potential will change gradually from the time the current pulse starts until the end of the simulation. This ensures that mismatches at the boundaries between adjacent simulation segments would be revealed by obvious, abrupt changes in the time course of recorded membrane potential.
For these reasons, my conceptual model is merely a spherical passive cell, with surface area 100 um2, driven by a current clamp that injects a constant current. The variable to be recorded is membrane potential. The model's membrane time constant and the duration of the injected current should be long enough that membrane potential will change gradually from the time the current pulse starts until the end of the simulation. This ensures that mismatches at the boundaries between adjacent simulation segments would be revealed by obvious, abrupt changes in the time course of recorded membrane potential.