The model consists of three hierarchical areas attempting to minimize reconstruction errors in inference and learning.
Age-dependent accumulation of amyloid-b, provoking increasing brain amyloidopathy, triggers abnormal patterns of neuron activity and circuit synchronization in Alzheimer’s disease (AD) as observed in human AD patients and AD mouse models.
The project was initiated to determine the projections of the orbital frontal cortex (OFC) to the parahippocampal region in the rat, using the anterograde tracers biotinylated dextran amine (BDA) and Phaseolus vulgaris-leucoagglutinin (PHA-L).
This dataset contains the Julich-Brain Atlas, Cytoarchitectonic maps in different coordinate spaces.
In this tutorial, you will warp an example MRI scan to MNI ICBM 152 2009c Nonlinear Asymmetric space and analyze a point of the input space in the detailed anatomical context of the EBRAINS Human Brain Atlas.
voluba-mriwarp is a desktop application for aligning human MRI scans to MNI152 template and analyzing brain regions.
voluba is a browser-based tool for interactive alignment of volumes of interest to 3D atlases.
A tutorial on how to anchor partial volumetric data to BigBrain using voluba.
The MIP interface currently integrates 14 algorithms for data analysis, applicable in subsets to the different pathologies.
Watch a demonstration of the Human Intracerebral EEG Platform.
This tutorial guides the user through the process of setting up and running RAMD simulations for estimation of the relative residence time (τ) of a protein-small molecule complex using the GROMACS software. The procedure is demonstrated for a complex of a low molecular weight compound with the N-terminal domain of the heat shock protein, HSP90.
This course contains an introduction to currently available reference atlases for mouse and rat brain. It will demonstrate how the 3D brain templates for the reference atlases are acquired, how they are used as a basis for delineating the structures of the brain, how they can be enriched by other data modalities, and how they can be used as a basis for assigning location (coordinate based or semantic) to a wide range of structural and functional data collected from the brain.
The single entry point to tutorials for EBRAINS tools and services. Here, you can find a list of EBRAINS offerings, sorted by topic, and links to their tutorials.
Modeling in neuroscience occurs at the intersection of different points of view and approaches. Typically, hypothesis-driven modeling brings a question into focus so that a model is constructed to investigate a specific hypothesis about how the system works or why certain phenomena are observed. Data-driven modeling, on the other hand, follows a more unbiased approach, with model construction informed by the computationally intensive use of data.
Interplay between the second messengers cAMP and Ca2+ is a hallmark of dynamic cellular processes. A common motif is the opposition of the Ca2+-sensitive phosphatase calcineurin and the major cAMP receptor, protein kinase A (PKA). Calcineurin dephosphorylates sites primed by PKA to bring about changes including synaptic long-term depression (LTD).
Dynamical models describing intracellular phenomena are increasing in size and complexity as more information is obtained from experiments. These models are often over-parameterized with respect to the quantitative data used for parameter estimation, resulting in uncertainty in the individual parameter estimates as well as in the predictions made from the model. Here we combine Bayesian analysis with global sensitivity analysis (GSA) in order to give better informed predictions; to point out weaker parts of the model that are important targets for further experiments, as well as to give guidance on parameters that are essential in distinguishing different qualitative output behaviours.
Neuroscience incorporates knowledge from a range of scales, from single molecules to brain wide neural networks. Modeling is a valuable tool in understanding processes at a single scale or the interactions between two adjacent scales and researchers use a variety of different software tools in the model building and analysis process. Here we focus on the scale of biochemical pathways, which is one of the main objects of study in systems biology.
This study includes 40 mice (20 at 6 months(m), 20 at 14 months(m); 2 males and 38 females). Of the mice, 29 are from 14 AD-BXD strains, 2 are the C57B1/6J founder strain, 6 are the F1 B6/DBA/2J (D2) 5XFAD founder strain, and 3 are nontransgenic (Ntg)-BXD.
Results: 1 - 18 of 55
EBRAINS is open and free. Sign up now for complete access to our tools and services.