The EBRAINS human brain atlas integrates different facets of brain organisation, represented by complementary maps of structure, function and connectivity that are defined across multiple reference spaces, going down to the micrometer resolution of the BigBrain model. The atlas can be explored using the 3D Interactive Atlas Viewer, as well as through different programmatic interfaces soon available on EBRAINS.
The multilevel human brain builds on the Julich-Brain cytoarchitectonic maps as a unifying principle of organisation, which are defined at the microscopic scale and well established as a reference for anatomical assignment of neuroimaging signals. The maps reflect intersubject variability in space and localization (“probability maps”). They are complemented with maps that cover complementary aspects of brain organisation, currently represented by fiber bundles from MRI tractography and maps of functional modes (DiFuMo). The atlas supports the MNI Colin27 and ICBM 2009c nonlinear asymmetric spaces to reflect the macroanatomical scale, which are common in functional imaging and whole-brain connectivity studies. It combines those with the microscopic resolution BigBrain model to represent brain organisation at the cellular level. Different brain regions are characterised by multiple levels of brain connectivity and a growing selection of multimodal data features, including transmitter receptor densities, cell distributions, and physiological recordings.
EBRAINS is developing a Python client, HTTP API and command line interface (CLI) to provide programmatic access to all the maps, data features and functions of the Human Brain Atlas. These will allow you to build automated workflows for retrieving information about regions, maps, and multi-modal data features, and to make use of the EBRAINS Human Brain Atlas for data analysis and modelling. First releases of these interfaces will be available in 2021. Stay connected, or get in touch with us if you are interested in testing an early release.
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